Synthesis method of alpha phenyl ethanol

一种α-苯乙醇的合成方法

Abstract

本发明提供了一种α-苯乙醇的合成方法,尤其是苯乙酮原位加氢合成α-苯乙醇的方法。所述的方法是以苯乙酮为原料,于C1~C4的脂肪醇与水的混合溶液中,在雷尼镍催化剂作用下,在50~300℃、0.1~10.0MPa条件下,一步反应得到所述的α-苯乙醇;所述苯乙酮∶C1~C4的脂肪醇∶水的物质的量之比为1∶2.5~60∶10~160。本发明的有益效果主要体现在:苯乙酮加氢还原不需要外部提供氢气,消除了氢气制备、存储和输送等环节的安全问题,工艺简化、生产成本降低;使用非贵金属雷尼镍催化剂,显著降低催化剂的成本和消耗;苯乙酮转化率较高,α-苯乙醇的选择性达到90%以上,生成少量副产物;通过分离即可得到高纯度的α-苯乙醇。
The present invention relates to alpha-phenyl ethyl alcohol synthesizing process, and is especially one in-situ acetophenone hydrogenating process of synthesizing alpha-phenyl ethyl alcohol. Inside the mixed solution of C1-C4 fatty alcohol and water and under the action of Raney nickel catalyst, acetophenone is one-step reacted at 50-300 deg.c and 0.1-10.0 MPa to obtain alpha-phenyl ethyl alcohol. The weight ratio of acetophenone, C1-C4 fatty alcohol and water is 1 to 2.5-60 to 10-160. The present invention has the beneficial effects of no need of outer hydrogen supply, simple technological process, low production cost, use of non-noble metal Raney nickel catalyst, high acetophenone converting rate, high alpha-phenyl ethyl alcohol selectivity up to 90 %, less side products and capacity of separating high purity alpha-phenyl ethyl alcohol.

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    CN-102603473-AJuly 25, 2012河北科技大学Method for preparing corresponding alcohol through carbonyl compound selective hydrogenation